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  • No-spa 0.04 N24 tab

The composition of Drotaverine hydrochloride 40 mg, excipients: magnesium stearate, talc, polyvidone, corn starch, lactose monohydrate. Pharmacological action: Antispasmodic. Drotaverine is a derivative of isoquinoline, which shows antispasmodic effect on smooth muscles by inhibiting the enzyme phosphodiesterase 4 (ФДЭ4). The inhibition of the enzyme ФДЭ4 leads to increased camp concentration, which inactivates the light chain myosin kinase (MLCK), which in turn leads to relaxation of smooth muscles. Drotaverine inhibits the enzyme ФДЭ4 in vitro no inhibition of PDE5 isoenzymes ФДЭ3 and. Apparently, ФДЭ4 functionally very important to reduce the contractility of smooth muscle, therefore, selective inhibitors ФДЭ4 can be effective in the treatment of hyperkinetic diseases and disorders associated with spastic conditions of the gastrointestinal tract. The enzyme which hydrolyzes cyclic amp in smooth muscle cells of the myocardium and blood vessels, mainly the isoenzyme ФДЭ3, which explains the high effectiveness of antispasmodic drotaverine as in the absence of pronounced actions on the cardiovascular system and serious cardiovascular adverse reactions. The drug is effective in spasms of smooth muscles as the nervous and muscular etiology. Regardless of the type of autonomic innervation of drotaverine acts on the smooth muscles of the gastrointestinal tract, biliary tract, and the urogenital and vascular systems. Thanks to the vasodilator action of no-Spa improves blood flow to the tissues. Pharmacokinetics Absorption and distribution When administered and parenterally administered drotaverine is rapidly and completely absorbed. Cmax achieved within 45-60 min. is Associated with plasma proteins (alpha-albumin, alpha and beta globulins). Metabolism and excretion Metabolized in the liver. T1/2 – 16-22 h. after 72 h drotaverine is excreted mainly as metabolites, 50% - with urine, 30% in the feces. Side-effects From the digestive system: rarely – nausea, constipation. CNS: rarely – headache, dizziness, insomnia. Of the cardiovascular system: rarely- palpitations; very rarely – hypotension. Other: very rarely – allergic reactions (for parenteral administration, particularly in patients with hypersensitivity to bisulphite). Features sale without prescription Special conditions In the composition of the tablets includes 52 mg of lactose, and the drug is in the form of pills not prescribed to patients with lactase deficiency, galactosemia or syndrome of impaired absorption of glucose/galactose. The composition of the solution for in/in and/m introduction part of sodium bisulfite, which can cause allergic reactions, including anaphylaxis and bronchospasm, in sensitive individuals (especially in persons with bronchial asthma or allergic reactions in history). In case of hypersensitivity to sodium metabisulfite parenteral administration of the drug should be avoided. Effects on ability to drive vehicles and management mechanisms When administered at therapeutic doses drotaverine does not affect the ability of engaging in potentially hazardous activities. After injection (especially) the introduction of the drug is recommended to refrain from driving vehicles and management mechanisms for 1 h (after application). Indications — spasms of the smooth muscles associated with diseases of the biliary tract cholelithiasis, cholecystitis, periholetsistit, cholangitis, papillitis; — spasms of smooth muscles of the urinary tract: nephrolithiasis, pyelitis, cystitis, tenesmus of the bladder; — in physiological delivery shortening phase of cervical dilatation and thereby reduce the total duration of labor (for solution for in/in and/m introduction). As adjuvant therapy: — spasm of smooth muscles of the digestive tract: ulcers disease stomach and duodenal ulcer, gastritis, spasms of the cardia and pylorus, enteritis, colitis, accompanied by constipation and flatulence; — tension headaches (for the reception inside); — gynecological diseases (dysmenorrhea); — strong contractions (for solution for in/in and/m introduction). When used in an adjuvant the drug is administered parenterally if you cannot use tablets.

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No-spa 0.04 N24 tab

  • Product Code: 1211
  • Availability: In Stock
  • $16.00