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  • Migrenium 0,065 + 0,5 n20 tab

Millenium instructions for use Dosage form Tablets are oval, biconvex shaped coated white or almost white with line on one side. In the cross-section are visible two layers. The color of the kernel without the shell white or nearly white color. Composition active substance: paracetamol – 0,500 g, caffeine – 0,065 g. auxiliary substances: potato starch, cellulose microcrystalline, croscarmellose sodium, hyprolose (oxypropyl-cellulose), silica colloidal anhydrous, magnesium stearate, copovidone, talc, titanium dioxide, silicone emulsion (50 % solution) Pharmacological action Millenium - combined product whose action is determined by the components included in its composition. Caffeine has a stimulating (stimulates psychomotor centers of the brain), analeptic effect, enhances the effect of analgesics, eliminates drowsiness and fatigue, increases physical and mental performance. Effect on the cardiovascular system: increases the frequency and force of heart contractions (heart rate) increases blood pressure (BP) and hypotension (does not alter normal). Dilates the bronchi, biliary tract, blood vessels, skeletal muscle, heart, kidneys, constricts blood vessels of the abdominal organs. Lowers platelet aggregation. Stimulates the secretion of gastric glands, increases the basal metabolism, has a mild diuretic effect. Paracetamol - antipyretic and analgesic effect (by inhibiting cyclooxygenase (COX) and inhibition of synthesis of prostaglandins (Pg) affects the thermoregulation center in the hypothalamus and conduction of pain impulses in the Central nervous system (CNS). The drug inhibits cyclooxygenase I and II predominantly in the Central nervous system, by acting on centers of pain and thermoregulation. In the inflamed tissue cellular peroxidase neutralizes the effect of paracetamol on cyclooxygenase, which explains the almost complete lack of anti-inflammatory effect. The drug has no negative impact on water-salt metabolism (delay sodium and water) and mucous membranes of the gastrointestinal tract (GIT) due to the lack of influence on the synthesis of prostaglandins in peripheral tissues. The possibility of formation of methemoglobin is unlikely. The pharmacokinetics of Caffeine and its water-soluble salts are well absorbed in the intestine (including large). The half-life of the drug (T1/2) is about 5 hrs, some people, up to 10 hours most demetiliruetsa and oxidized. About 10% excreted by kidneys unchanged. Paracetamol is rapidly and almost completely absorbed from the gastrointestinal tract. Concentration in plasma reaches a peak in 30-60 min. T1/2 plasma 1 to 4 hours Metabolized in the liver. Excreted in the urine mainly in the form of esters with glukuronova and sulphuric acids; less than 5% excreted unchanged

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Migrenium 0,065 + 0,5 n20 tab

  • Product Code: 202
  • Availability: In Stock
  • $11.00