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  • Ketanov 0.01 n100 tab

Composition Ketorolac tromethamine 10 mg excipients: corn starch; microcrystalline; silica colloidal anhydrous; magnesium stearate film-shell: hydroxypropyl methylcellulose; polyethylene glycol 400 (macrogol 400); talc-purified; titanium dioxide; purified water (lost in the production process) Pharmacological action NSAIDs, a derivative pyrrolidin-carboxylato acid. Has a strong analgesic effect, also has anti-inflammatory and mild antipyretic action. The mechanism of action is associated with inhibition of the activity of COX, the main enzyme of arachidonic acid metabolism, which is a precursor to prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever. Cmax in plasma is reached in 40-50 min after the ingestion and after the/m introduction. Food intake has no effect on absorption. The plasma protein binding is more than 99%. T1/2 - 4-6 hours both after oral administration and after the / m introduction. More than 90% of the dose is excreted in the urine, unchanged - 60%; the remaining amount-through the intestine. In patients with impaired renal function and senile age, the rate of excretion decreases, T1/2 increases Side effects from the cardiovascular system: rarely-bradycardia, changes in blood PRESSURE, palpitations, fainting. From the digestive system: possible nausea, abdominal pain, diarrhea; rarely-constipation, flatulence, a feeling of overcrowding, vomiting, dry mouth, thirst, stomatitis, gastritis, erosive-ulcerative lesions of the gastrointestinal tract, liver dysfunction. From the Central and peripheral nervous system: possible anxiety, headache, drowsiness; rarely-paresthesia, depression, euphoria, sleep disorders, dizziness, changes in taste, visual impairment, motor disorders. The respiratory system: rarely - violation of breath, asthma attacks. From the urinary system: rarely – increased frequency of urination, oliguria, polyuria, proteinuria, hematuria, azotemia, acute renal failure. From the blood clotting system: rarely-nosebleeds, anemia, eosinophilia, thrombocytopenia, bleeding from postoperative wounds. Metabolism: may increase sweating, swelling; rarely-oliguria, increased levels of creatinine and / or urea in blood plasma, hypokalemia, hyponatremia. Allergic reactions: possible skin itching, hemorrhagic rash; in isolated cases-exfoliative dermatitis, urticaria, Lyell syndrome, Stevens-Johnson syndrome, anaphylactic shock, bronchospasm, Quincke edema, myalgia. Other: possible fever. Local reactions: pain at the injection site. Special conditions are used with caution in patients with impaired liver and kidney function, chronic heart failure, arterial hypertension, in patients with erosive and ulcerative lesions of the gastrointestinal tract and bleeding from the gastrointestinal tract in a history. Ketorolac should be used with caution in the postoperative period in cases where particularly careful hemostasis is required (including after resection of the prostate gland, tonsillectomy, in cosmetic surgery), as well as in patients of senile age, as well. the half-life of Ketorolac is extended, and plasma clearance may decrease. In this category of patients, Ketorolac is recommended in doses close to the lower limit of the therapeutic range. If you have symptoms of liver damage, skin rash, eosinophilia Ketorolac should be discontinued. Ketorolac is not indicated for use in chronic pain syndrome. Effects on ability to drive vehicles and management mechanisms If during the period of treatment with Ketorolac appear drowsiness, dizziness, insomnia or depression, you need to exercise special care during classes potentially hazardous activities, require increased attention and psychomotor speed reactions. Indications For short-term relief of moderate to severe pain of various origins.

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Ketanov 0.01 n100 tab

  • Product Code: e7
  • Availability: In Stock
  • $23.50