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  • Ornidazole 0.5 N10 tab

Composition орнидазол500 mg excipients:lactose (milk sugar), cellulose microcrystalline, povidone (polyvinylpyrrolidone), sodium lauryl sulfate, calcium stearate, silicon dioxide colloidal (Aerosil), Primerose (croscarmellose sodium), hypromellose (hydroxypropylmethylcellulose), macrogol 4000 (polyethylene glycol 4000), talc, titanium dioxide. Pharmacological action Antiprotozoal remedy, a derivative of 5-nitroimidazole. I believe that the mechanism of action is associated with disruption of the structure of DNA of sensitive microorganisms. Active against Trichomonas vaginalis, Giardia lamblia, Entamoeba histolytica, and also against certain anaerobic bacteria (including Bacteroides spp. Clostridium spp. Fusobacterium and anaerobic cocci) the half-life of Ornidazole is greater than metronidazole. Pharmacokinetics Absorption After intake of Ornidazole is rapidly absorbed in the gastrointestinal tract. Bio availability of the drug reaches 90 %. Maximum plasma concentrations are achieved within 3 hours. The distribution of Binding Ornidazole protein is about 13 %. The active substance passes into breast milk and most tissues, cerebrospinal fluid, other body fluids, passes through the blood-brain barrier and the placenta. The concentration of Ornidazole in plasma are in the range 6-36 mg/l, i.e. at the level deemed optimal for the various indications for the use of the drug. The metabolism of Ornidazole metaboliziruetsa in the liver with the formation of mainly 2-gidroksimetil - and gidroximetabolitov. Both metabolites are less active against Trichomonas vaginalis and anaerobic bacteria than the unmodified Ornidazole. Excretion the elimination half-life is about 13 hours. After a single dose, 85% of the dose was excreted within the first 5 days. In the form of metabolites excreted by the kidneys 60-80% and bowel 20-25%. About 4% of the dose is excreted via the kidneys in unchanged form. Side-effects From the digestive system: nausea, heartburn, dizziness, drowsiness, skin rash. From the nervous system: possible headache, dizziness, impaired consciousness, tremor, muscle rigidity, violation of coordination of movements, cramps, sensory or mixed peripheral neuropathy, nausea, vomiting, diarrhea. Especially sales prescription Special conditions inhibits alcohol dehydrogenase, and therefore not incompatible with alcohol. Indications Trichomoniasis (genitourinary infections in women and men, caused by Trichomonas vaginalis); ambias (all of intestinal infections caused by Entamoeba histolytica, including amoebic dysentery, all extraintestinal forms of amoebiasis, especially amoebic liver abscess); giardiasis. Prevention of anaerobic infections during operations on the colon and gynecological interventions. Contraindications Hypersensitivity to Ornidazole or to other nitroimidazole derivatives, components of the drug. Children up to age 3'syears, and body weight less than 20 lbs. the first trimester of pregnancy, the breastfeeding period. Pathological changes of the blood and abnormalities of the cells With caution in liver Disease, alcoholism, pregnancy II and III trimester, children aged 3 years and weighing more than 20 kg, in elderly patients. Application during pregnancy and lactation Ornidazole is contraindicated in the first trimester of pregnancy and during breastfeeding. In the experiment Ornidazole has no teratogenic or toxic effects on the fetus. Since controlled studies in pregnant women have not been conducted, apply Ornidazole in II and III trimestrah pregnancy is possible only if absolutely indicated when the possible benefits of its application for mother exceeds potential risk to the fetus. Organic diseases of the Central nervous system. Drug interactions Potentiates the effect of indirect anticoagulants, increases the duration of action of vecuronium bromide.

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Ornidazole 0.5 N10 tab

  • Product Code: 48
  • Availability: In Stock
  • $10.00


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