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  • Metrogil 1% 30.0 GEL WAG

Composition metronidazole 10 mg excipients: propylhydroxybenzoate, propylene glycol, carbomer-940, disodium edetate, sodium hydroxide, water. Pharmacological action: Metronidazole has high activity against Trichomonas vaginalis, Gardnerella vaginalis, Giardia intestinalis, Entamoeba histolytica, and obligate anaerobes Bacteroides spp. (including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides viilgatus), Fusobacterium spp., Veillonela spp. Prevotella (P. bivia, P. buccae. P. disiens) and some gram-positive bacteria (Eubacterium spp., Clostridium spp. Peptococcus spp., Peptostreptococcus spp., Mobiluncus spp.). Minimum overwhelming concentration for these strains is 0.125–6.25 mcg/ml. the Mechanism of action Metrogel is to restore the biochemical 5-nitro group of metronidazole intracellular transport proteins anaerobic microorganisms and protozoa. Restored 5-nitro group of metronidazole interacts with DNA cells of microorganisms by inhibiting the synthesis of their nucleic acids, leading to death of bacteria. Pharmacokinetics After a single intravaginal administration of 5 g Metrogel average Cmax of the drug in the blood serum of 237 ng/ml, which is 2% of the average Cmax of metronidazole when administered doses of 500 mg. the Time to reach Cmax is 6-12 h after intravaginal application of a single dose of 5 g and 1-3 h after oral administration of metronidazole at a dose of 500 mg. After intravaginal administration of the drug exposed systemic absorption (about 56%). Enters breast milk and most tissues, passes the blood-brain barrier and the placenta. Linking blood plasma - less 20%. Metabolized in the liver by hydroxylation, oxidation and glukuronirovania. The activity of the main metabolite (2-oximetronidazol) - 30% activity of the parent compound. The relative bioavailability of vaginal gel is 2 times higher bioavailability of a single dose (500 mg) vaginal tablets of metronidazole, due to the high penetrating ability of the drug in vaginal fluid. Therefore, the therapeutic effects after intravaginal administration is achieved already at low concentrations of metronidazole. Excreted by the kidneys - 60-80% of the dose of the drug for systemic effects (20% in unchanged form), intestines - 6-15% of the dose of systemic action. Side effects Local reactions: burning sensation or frequent urination, vulvitis; the sexual partner is a burning sensation or irritation of the penis. After discontinuation of the drug is the development of vaginal candidiasis. Perhaps the development of systemic effects: dizziness, headache, dry mouth, taste changes, including metallic taste, nausea, vomiting, reduced appetite, spasticskie pains in the abdomen, constipation or diarrhea, staining of urine in dark color, leukopenia or leukocytosis. Allergic reactions: skin rash, urticaria. In case of any unwanted side effects should stop treatment and seek medical attention. Features sale without prescription Special conditions during the period of treatment contraindicated use of alcohol (perhaps the development disulfiramopodobnaya reactions: spastic abdominal pain, nausea, vomiting, headache, a sudden rush of blood to the face). Metrogyl® may immobilize Treponema and lead to false positive test Nelson. During treatment should refrain from sexual activity. Avoid contact with eyes. Indications — bacterial vaginosis different etiology, confirmed by clinical and microbiological data; — urogenital trichomoniasis. Contraindications: leukopenia (including in the anamnesis); — impaired coordination; — organic lesions of the Central nervous system (including epilepsy); — liver failure; — pregnancy - the first trimester; — hypersensitivity (W. to nitroimidazole derivatives). Drug interactions Similar to disulfiram causes intolerance of ethanol. Increases the effect of indirect Aitmagambetov, it is not recommended to combine with non-depolarizing muscle relaxants (vecuronium). At simultaneous reception with preparations of lithium may increase the concentration of lithium in the blood plasma. Phenobarbital accelerates metabolism of metronidazole due to induction of microsomal liver enzymes, cimetidine reduces.

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Metrogil 1% 30.0 GEL WAG

  • Product Code: 37
  • Availability: In Stock
  • $15.00


Tags: Metrogil 1% 30.0 GEL WAG