Pharmaceutical form clear, colorless or almost colorless liquid of the Composition To 1.0 g of the preparation contains: Active substance: amorolfine hydrochloride - 64,0 mg, which corresponds to amorolfine base - 57,4 mg. excipients: methyl methacrylate, trimetilammoniietilakrilata chloride and etilakrilata copolymer [1:2:0.2] - 143,0 mg, triacetin to 12.0 mg, butyl acetate - 57,0 mg, ethyl acetate - 172,0 mg, ethanol absolute 552,0 mg. Pharmacological action Antifungal drug for external use. Provides fungistaticescoe and fungicidal effect due to damage to the cytoplasmic membrane of the fungus by interfering with the biosynthesis of sterols. Reduced content of ergosterol and the accumulation of atypical content sterically nonplanar sterols. It has a wide spectrum of action. Highly active against both the common and rare pathogens of fungal nail infections: Dermatophytes: Trichovhvton svv., Microsporum spp. Epidermophyton spp. Yeast fungi: Candida spp. Cryptococcus spp. Malassezia spp. (Pityrosporum spp.). Fungi: Alternaria spp., Scopulariopsis spp. Hendersonula spp. Fungi of the family Dematiaceae: Cladopsorium spp. Fonsecaea spp. Wangiella spp. Dimorphic fungi: Coccidioides spp. Histoplasma spp. Sporothrix spp. Pharmacokinetics When applied on the nails penetrates the nail plate and further to the nail bed (almost completely within the first 24 hours). Effective concentration is maintained in the affected nail plate within 7-10 days after the first application. Systemic absorption is negligible: the concentration in plasma is below the detection limit methods for the determination (less than 0.5 ng/ ml).
Loceryl 5% 2.5ml flake varnish for nails
- Product Code: 36
- Availability: In Stock