Composition fluconazole 50 mg excipients: silica colloidal anhydrous (Aerosil), starch corn, magnesium stearate, sodium lauryl sulfate, lactose. The composition of the shell capsules: gelatin, dye iron oxide red (E172), methyl parahydroxybenzoate, parahydroxybenzoate, titanium dioxide (E171), acetic acid. Pharmacological action Antifungal drug. Fluconazole is representative of a class of triazole antifungal agents, is a powerful inhibitor selective synthesis sterols in the cell mushrooms. Active against causative agents of opportunistic mycoses, including caused by Candida spp. Cryptococcus neoformans, Microsporum spp., Trichophyton spp. Also shown is the activity of fluconazole on models of endemic mycoses, including infections caused by Blastomyces dermatitidis, Coccidioides immitis and Histoplasma capsulatum. Pharmacokinetics Absorption After oral fluconazole is well absorbed. Bioavailability is 90%. Cmax of fluconazole in plasma after ingestion on an empty stomach in the dose of 150 mg is 90% of its content in the plasma during in/in the introduction in a dose of 2.5-3.5 mg/l. Tmax is achieved through 0.5-1.5 h after administration. Simultaneous eating does not affect the absorption when taken orally. Plasma concentration is directly proportional to the dose. The distribution of 90% of Css is achieved by the 4-5 day of treatment (when receiving a 1 times/). Introduction of shock dose (in 1 day), 2 times the average daily dose, allows you to achieve 90% level Css to the 2nd day. Apparent Vd is approaching to the total water content in the body. Linking protein - 11-12%. Fluconazole penetrates well into all body fluids organism. Concentration of fluconazole in saliva and sputum are similar to concentrations in plasma. In patients with fungal meningitis the concentration of fluconazole in spinal fluid is about 80% from levels in plasma. In the stratum corneum, the epidermis, derma and sweat are reached high concentrations, that exceed the whey. The elimination T1/2 is about 30 h. fluconazole write mainly kidneys; about 80% imposed dose found in the urine in unchanged form. Fluconazole clearance is proportional to KK. Metabolites of fluconazole in the blood is not detected.

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  • Product Code: 11
  • Availability: In Stock
  • $21.99