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  • Doxycycline 0.1 N20 CAPS

Composition Active substance: Doxycycline hydrochloride - 0.1 g excipients: calcium stearate, potato starch, milk sugar (lactose). Hard gelatin capsule: gelatin, glycerin, nipagin, nipazol, sodium lauryl sulfate, dyes: E-133 (Brilliant blue); E-110 (sunset); E-129 (alyur red); E-104 (Quinoline yellow); E-171 (Titanium dioxide), calcium stearate, potato starch, milk sugar Pharmacological action Semisynthetic tetracycline, a bacteriostatic broad-spectrum antibiotic derived from metatsiklina. Penetrating inside the cell, acts on intracellular pathogens located. Inhibits protein synthesis in the microbial cell, disrupting the communication transport aminoacyl-RNA to 30S ribosomal subjedinice of the membrane. Does not affect the cell wall synthesis of bacteria. To him highly sensitive: gram-positive microorganisms Staphylococcus spp. (including Staphylococcus aureus, Staphylococcus albus), Streptococcus spp. (including Streptococcus pneumoniae), Clostridium spp., Listeria spp.; and gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae, Klebsiella spp., Entamoeba histolytica, E. coli, Shigella spp., Enterobacter, Salmonella spp., Pasterella spp., Bacteroides spp. Psyttacosis spp. Treponema spp. (including strains resistant to other antibiotics, e.g. modern penicillins and cephalosporins). The most sensitive Haemophilus influenzae (91-96%) and intracellular pathogens. Pharmacokinetics Absorption - rapid and high (about 100%). Has a high degree of solubility in lipids and low affinnosti in binding calcium. After oral administration of 200 mg, the time to maximum concentration, 2.5 h, the maximum concentration is 2.5 µg/ml, 24 h after admission - 1.25 µg/ml. the Connection with plasma proteins is 80-90%. Well into the organs and tissues; 30-45 min after ingestion detected in therapeutic concentrations in the liver, kidneys, lungs, spleen, bones, teeth, prostate gland, eye tissue, in pleural and ascitic fluids, bile, synovial exudate, the exudate of the maxillary and frontal sinuses. Poorly penetrates into the cerebrospinal fluid (10-20% of plasma levels). Penetrates through the placental barrier, is identified in breast milk. Metabolized in the liver 30-60%. The half-life is 16-24 h. after repeated administration of the drug can koumoulirovati. Accumulates in bone tissue. In the bones and teeth, it forms insoluble complexes with calcium. Excreted in the bile, which is found in high concentrations. Exposed kishechnopolostnyh recycling is excreted in feces (20-60%); 40% of the dose excreted by the kidneys in 72 h (20-50% in an unmodified form), and severe chronic renal failure - only 1-5%. In patients with impaired renal function or azotemia an important way of excretion is the gastrointestinal tract.

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Doxycycline 0.1 N20 CAPS

  • Product Code: 9
  • Availability: In Stock
  • $4.00


Tags: Doxycycline 0.1 N20 CAPS